Management of multiple myeloma linkedin slideshare. Disease overview craig emmitt cole, md university of michigan comprehensive cancer center. Treatment guidelines for newly diagnosed multiple myeloma. When plasma cells reproduce uncontrollably, two things happen. The survival time of patients with plasmocytic myeloma. Multiple myeloma early detection, diagnosis, and staging 1. In healthy people, plasma cells make up 23 % of the cells in the bone. Edited and written by a multidisciplinary group of recognized.
This article summarises the current status and highlights how an understanding of both is necessary. Multiple myeloma accounts for around 1% of all cancers worldwide and 1015% of all hematological neoplasms. Recent advances have resulted in improved treatment options and remission rates, writes mary kelly. Pdf multiple myeloma is an incurable hematological disease previously associated with poor prognosis and survival rates.
Multiple myeloma is considered a cancer of plasma cells, and nonhodgkin lymphoma is a cancer of lymphocytes. Myeloma begins when healthy plasma cells in the bone. Pdf multiple myeloma mm is a plasma cell dyscrasia that accounts for 10% of haematological malignancies. Pdf on nov 29, 2005, alastair smith and others published guidelines on the diagnosis and management of multiple myeloma 2005 find. Multiple myeloma is a type of cancer that targets the plasma cells in bone marrow. The imfs patient handbook is designed to help you to understand multiple myeloma which we refer to simply as myeloma. Myeloma is called multiple because it frequently involves multiple areas in the body. You wont have to go far to receive multiple myeloma treatment support because there are helpful resources right here on. This guideline covers the diagnosing and managing of myeloma including smouldering myeloma and primary plasma cell leukaemia in people aged 16 and over. Read a 1page fact sheet that offers an introduction to multiple myeloma. Musculoskeletal bone pain pathological fracture hypercalcemia.
Current management of multiple myeloma december 2012 kevin song md frcpc. Multiple myeloma early detection, diagnosis, and staging. Myeloma is a cancer of the plasma cells in the bone marrow, the spongy tissue inside of bones. Multiple myeloma is a disease in which a neoplastic proliferation of plasma cells produces a monoclonal immunoglobulin. The changing paradigm highdose chemotherapy and stem cell transplantation todd zimmerman, md university of chicago medical center. Wm cells have features of both plasma cells and lymphocytes. European myeloma network guidelines for the management of. Thalidomide in combination with an alkylating agent and a corticosteroid is recommended as an option for the firstline treatment of multiple. Multiple myeloma mm, also known as symptomatic plasma cell myeloma, is a plasma cell malignancy. Patients may present with bone pain or with symptoms that are often nonspecific, such as nausea. Multiple myeloma mm is a cancer of the plasma cells in the bone. Multiple myeloma accounts for approximately 10% of hematologic malignancies. In germany there are around 6500 new cases of multiple myeloma each.
It aims to improve care for people with myeloma by promoting the most effective tests and treatments for myeloma and its complications. This is a comprehensive, stateoftheart guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. The european myeloma network provides recommendations for the management of the most common complications of multiple myeloma. The management of multiple myeloma from the hematology laboratory rufts, boston city hospital, boston, massachusetts william c. Review article multiple myeloma world health organization. A change in the bone marrow or a mutation in a plasma cells dna. Fundamentals in the management of multiple myeloma med j malaysia vol 65 no 3 september 2010 233 system clinical manifestation 1. Our increased understanding of myeloma biology has resulted in significantly improved patient outcomes. Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. Multiple myeloma mm, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies.
Myeloma canada is a registered nonprofit organization created by, and for, people living with multiple myeloma. Management of multiple myeloma research to practice. Advances in the imaging and treatment of multiple myeloma have occurred over the past decade. Pdf guidelines on the diagnosis and management of multiple.
Multiple myeloma causes cancer cells to accumulate in the bone marrow, where they crowd out healthy blood cells. Learn more about the symptoms, causes, diagnosis, risk factors, and treatment of multiple myeloma. Multiple myeloma accounts for 1% of all cancers and approximately 10% of all haematological malignancies. This fact sheet is available as a pdf, so it is easy to print out.
Since 2015, a number of novel agents have been approved by the fda food drug administration for the treatment of mm. Crab hypercalcemia, renal failure, anemia, or lytic bone lesions features felt related to the plasma cell disorder, bone marrow clonal plasmacytosis. These updated esmo clinical practice guidelines cover the diagnosis and pathologymolecular biology, staging and risk assessment and response evaluation of multiple myeloma. Multiple myeloma is the second most common type of blood cancer after leukemia. Pdf an approach to the diagnosis and management of multiple. What are the most suitable management strategies of multiple myeloma and related. Plasma cells help you fight infections by making antibodies that recognize and attack germs. Initial treatment consists of bortezomib, lenalidomide, dexamethasone vrd.
Multiple myeloma mm is an aggressive malignant neoplasm of plasma cells that accumulates in the bone. It is characterised by a clonal population of bone marrow plasma cells which secrete a monoclonal paraprotein or an immunoglobulin free light chain flc figure 1a, b. Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. As the only national organization exclusively devoted to the canadian myeloma community. Abstract multiple myeloma accounts for approximately 10% of hematologic. Mayo clinic college of medicine mayo clinic comprehensive cancer center current approaches to managing multiple myeloma shaji kumar, m. Multiple myeloma mm is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance mgus to plasma cell leukemia.
Multiple myeloma, the most common bone malignancy, is occurring with increasing frequency in older persons. What are the most suitable management strategies of multiple myeloma and related disorders. It may present with myriad complications including anaemia, hypercalcaemia, renal failure, recurrent infections or bony lytic. Multiple myeloma is a cancer of certain cells of the bone marrow called plasma cells. Multiple myeloma accounts for 1% of all cancers and approximately 10% of all hematologic malignancies. The patient handbook focuses on the questions and decisions that a newly diagnosed patient faces. Multiple myeloma is slightly more common in men than in women and the median age at the time of diagnosis is about 65 years. Share in the message dialogue to help others and address questions on symptoms. Learning objectives compare treatment strategies employed by community oncologists, hematologyoncology fellows and cancer clinical investigators.
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